Engineering biological gradients

Engineering biological gradients

Blog Article

Biological gradients profoundly influence many cellular activities, such Ball - Batter - Helmet as adhesion, migration, and differentiation, which are the key to biological processes, such as inflammation, remodeling, and tissue regeneration.Thus, engineered structures containing bioinspired gradients can not only support a better understanding of these phenomena, but also guide and improve the current limits of regenerative medicine.In this review, we outline the challenges behind the engineering of devices containing chemical-physical and biomolecular gradients, classifying them according to gradient-making methods and the finalities of the systems.

Different manufacturing processes can generate gradients in either in-vitro systems or scaffolds, which are suitable tools for the study of Nail Tips cellular behavior and for regenerative medicine; within these, rapid prototyping techniques may have a huge impact on the controlled production of gradients.The parallel need to develop characterization techniques is addressed, underlining advantages and weaknesses in the analysis of both chemical and physical gradients.